Media Update: Sanofi completes closing for potential first-in-class vaccine against extraintestinal pathogenic E.coli (ExPEC)

Sanofi completes closing for potential first-in-class vaccine against extraintestinal pathogenic E. coli (ExPEC)

Paris, November 9, 2023. Sanofi announces today completion of closing for its collaborative agreement with Janssen Pharmaceuticals, Inc. (Janssen), a Johnson & Johnson company to develop and commercialize the vaccine candidate for extraintestinal pathogenic E. coli (9-valent) (ExPEC9V).

Extraintestinal pathogenic E. coli (ExPEC) has been identified as the leading bacterial cause of sepsis, causing approximately 10 million cases of invasive ExPEC disease annually, worldwide.1,2 It is associated with increased hospitalizations, mortality and antimicrobial resistance resulting in significant healthcare and societal costs.3,4

Executive Vice President, Vaccines, Sanofi

At Sanofi, we believe in the power of partnership to deliver true innovation. In this case, we’re bringing together Janssen’s robust science and Sanofi’s worldwide manufacturing footprint and expertise in launching innovative vaccines. We look forward to delivering this potential first-in-class vaccine designed to help older adults around the world live longer, healthier lives.

ExPEC9V is currently being assessed via the Phase 3 E.mbrace trial which continues to enroll patients. Learn more about the trial here: https://classic.clinicaltrials.gov/ct2/show/NCT04899336

1 Russo TA and Johnson JR. Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem. Microbes Infect. 2003;5:449–456.

2 Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395(10219):200-211. doi:10.1016/S0140-6736(19)32989-7

3 O’Neill J. Antimicrobial Resistance: Tackling a crisis for the health and wealth of nations. Review on Antimicrobial Resistance. Available at: https://amr-review.org/sites/default/files/AMR%20Review%20Pa per%20-%20Tackling%20a%20crisis%20for%20the%20health%20and%20wealth%20of%20nations_1.pdf. Last accessed: October 2022.

4 Hernandez-Pastor L, Geurtsen J, Baugh B, et al. Economic burden of invasive Escherichia coli disease among older adult patients treated in hospitals in the United States. J Manag Care Spec Pharm. 2023;29(8):873-883. doi:10.18553/jmcp.2023.29.8.873

We are an innovative global healthcare company, driven by one purpose: we chase the miracles of science to improve people’s lives. Our team, across some 100 countries, is dedicated to transforming the practice of medicine by working to turn the impossible into the possible. We provide potentially life-changing treatment options and life-saving vaccine protection to millions of people globally, while putting sustainability and social responsibility at the center of our ambitions.

Sanofi is listed on EURONEXT: SAN and NASDAQ: SNY

Sandrine Guendoul | + 33 6 25 09 14 25 | [email protected]

Sally Bain | + 1 617 834 6026 | [email protected]

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